A former member of Chicago-based Second City and Annoyance Theatre comedy troupes, she is best known for her role as "Jerri Blank" in the television series Strangers with Candy. The show, which she co-wrote with Paul Dinello and Stephen Colbert was based on Sedaris' impression of 1970s motivational speaker Florrie Fisher.
Sedaris has appeared in the movies Elf, School of Rock, Maid in Manhattan, the film version of Bewitched and is featured in David Munro's upcoming Full Grown Men. She also starred in the 2006 film adaptation of Strangers with Candy. In addition to acting, she runs a cupcake and cheese ball business ("Dusty Food Cupcakes") out of her kitchen.
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